It turns your metabolic “master switch” back on—improving insulin sensitivity, fat burning, blood sugar control, and muscle glucose uptake.
Consultation Required?
Yes
Session Length
15 minutes
# of Sessions Needed
Varies
Results Duration
Varies
Who is this for:
On GLP-1s: protect muscle + metabolism
Off GLP-1s: avoid rebound
Insulin resistance
Metabolic slowdown
Perimenopausal shifts
Training with no results
...and more!
The future of metabolism is not hype, it is chemistry.
At Shot Bar, we don’t chase trends—we change physiology. O304 is a pharmaceutical-grade AMPK activator, not berberine off Amazon and not metformin with side effects. AMPK is your metabolic master switch: it tells your body to burn fat, improve insulin sensitivity, steady blood sugar, pull glucose into muscle, and boost mitochondrial energy. It delivers the cellular benefits of exercise and caloric discipline without wrecking your metabolism or mood.
If your body feels “stuck”—during weight loss, hormonal shifts, peri/menopause, or GLP therapy—your AMPK system is likely in low gear. We turn it back on. Activated AMPK shifts you into high-efficiency mode: muscles use glucose, fat becomes fuel, the liver stops hoarding fat, and mitochondria produce clean energy.
O304 directly activates AMPK. No stimulants. No crash dieting. Just metabolic precision.
What You Can Expect:
Fewer cravings
Steady blood sugar + energy
Easier fat loss (especially belly)
Better muscle response
Metabolic clarity over struggle
...and more!
It’s a PROGRAM
O304 is not meant to live alone. It performs best when it is part of a metabolic strategy. At Shot Bar, we do not throw random treatments at you and hope something sticks. We build metabolic advantage on purpose.
This therapy is prescribed based on your clinical history, labs, symptoms, and goals. Lindsey will review your current medications, GLP dosage (if applicable), hormone status, intake patterns, and overall metabolic profile before initiation.
AMPK Activation Therapy is part of our Metabolic Performance Medicine approach, which can also be paired with BHRT, peptide therapy, PRP and exosomes for hair restoration, Sofwave for collagen remodeling, Pure Impact for muscle tone, and clinical nutrition support directly with Lindsey.
The Play-by-Play
The Shot Bar Process
Step 1
Consultation
At Shot Bar, although you don’t need a consult for our Wellness Shots and Cocktails menu, we can advise you on the best vitamins to help to meet your health goals. We will talk with you and provide recommendations for vitamin injections to boost your beauty routine or health goals. Consultations are also a great time for us to get to know you and answer any questions that you may have.
Step 2
Treatment
Please let us know ahead of time if you are taking any additional vitamins or supplements. The injection is much like a vaccine and the entire appointment only takes about 15 minutes. Your treatment provider will make sure you are comfortable as they give you your vitamin injection. Then you’ll be on your way!
Step 3
Next Steps
There’s no aftercare required for our vitamin injections. These are a great way to level up your wellness game and benefit just about anyone! ShotBar recommends vitamin injections weekly for best results and we can run tests to find the best combination for you. We also offer four-pack bundle pricing, including for our most popular vitamin B12 shots in Lincoln Park!
Give Us a Shot
Looking for a wellness treatment in addition to our Metabolic AMPK Activation Therapy (O304)? Try our Treatment Builder Just input your concerns to get custom recommendations for treatments!
Trust Us, Gorgeous
At Shot Bar, we’re aesthetics magicians who don’t play around when it comes to skincare science. Shot Bar’s medical director, Lindsey Sikora MSN, APRN, FNP-BC, only chooses treatments that have been clinically proven. Her dream for Shot Bar was to offer a space for those who wanted to stand out—with originality and style. Shot Bar embraces the truth that aesthetics and wellness don’t have to be about sleepy, atmospheric lighting and white noise machines. We’re all about results.
Questions? We've Got The Answers
No. O304 is a pharmaceutical-grade AMPK activator with no stimulant effects and none of the GI side effects metformin is known for.
Anyone dealing with slow metabolism, insulin resistance, GLP rebound, perimenopausal shifts, or training hard without results.
Yes—AMPK therapy helps protect muscle, stabilize metabolism, and prevent the metabolic slowdown that often happens on GLP-1s.
